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N-Boc Piperazine (1-Boc-piperazine)

N-Boc Piperazine (1-Boc-piperazine)

N-Boc Piperazine, also known as 1-Boc-piperazine, is a protected form of piperazine commonly used as a pharmaceutical intermediate in the synthesis of active ingredients, especially in CNS and anti-infective drugs. Its Boc (tert-butoxycarbonyl) group serves as a protecting group during multi-step synthesis and can be removed under acidic conditions.

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Description

🔹 Key Details:

  • CAS Number: 57260-71-6
  • Molecular Formula: C₉H₁₈N₂O₂
  • Molecular Weight: 186.25 g/mol
  • Appearance: White to off-white crystalline powder
  • Solubility: Soluble in common organic solvents like dichloromethane and ethanol
  • Melting Point: 43–47°C

Application: Used in medicinal chemistry and drug discovery as a building block for piperazine-based APIs